Necrostatin-1; Inactive Control

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetInactive control for Nec-1 (Cat. No. 480065)

Cell permeable: yes

General description

A cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control. Note: This inactive inhibitor of necrosis should not be used in high concentration.

A cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control.r>r>Note: This inactive inhibitor of necrosis should not be used in high concentration.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Takahashi et al. 2012. Cell Death and Disease3, e437.Degterev, A., et al. 2005. Nat. Chem. Biol.1, 112.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)